Activation imaging of drugs with hybrid Compton camera: A proof-of-concept study

The visualization of drugs is essential for cancer treatment. Although several methods visualizing have been proposed, a versatile method that can be easily applied to various has not yet established. Therefore, we propose “activation imaging,” in which drug irradiated with thermal neutrons and becomes radioactive, enabling using emitted x rays and/or gamma rays. Activation imaging does require the conjugation specific tracers drugs. it variety drugs, carriers (e.g., metal nanoparticles), contrast agents. In this study, neutron activation, gamma-ray spectroscopy, carriers, anticancer drug, agents were performed. Gold nanoparticles (AuNPs) platinum used as cisplatin was an gadoteridol iohexol As source, RIKEN accelerator-driven compact source II (RANS-II) utilized. performed hybrid Compton camera (HCC). HCC visualize ranging from few keV nearly 1 MeV, enables activated result, spectra indicated generation radioisotopes through irradiation, AuNPs visualized.